Polyhexamethylene Biguanide Hydrochloride (PHMB)
CAS No.: 32289-58-0
Molecular Formula: (C8H18N5Cl)n, n=12-16
Structural Formula:
Properties:
Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer. It is a water solution that can be used as a broad spectrum and high efficient disinfectant. PHMB biocide is low toxic, steady, non-flammable, non-explosive and basically non-corrosive to stainless steel, copper, carbon steel, wood and plastic.
Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action. PHMB disinfectant is a high molecular polymer, which is easy to be washed away. It is non-corrosive to skin, and can not be easily absorbed by human organs. Vitro studies show that Polyhexamethylene biguanide hydrochloride is non-toxic to human cell. Skin irritancy test of rabits and human hands shows that PHMB is non-irritant to animal and human skin. Polyhexamethylene biguanide hydrochloride can be widely used in textile, animal husbandry, aquicultrue, medical sterilization and daily disinfectant.
Specifications:
| Item | Index | |
|---|---|---|
| Appearance | Colorless or light yellow liquid | Colorless or light yellow liquid |
| Active content | 20% Min. | 99% Min. |
| Ordor | None | Weak amine odor |
| pH (1% solution) | 4.0 Min. | 4.0 Min. |
| Density (g/ml, 20℃) | 1.040-1.050 | -- |
| Absorbance (1%, 236nm) (1%,236nm) | 400 Min. | 0.03 |
| Absorbance (236/220nm) | 1.2-1.6 | 1.2-1.6 |
| Moisture | -- | 0.5% Max. |
| Water insoluable | -- | 0.1% |
| Ash | -- | 0.05% |
| Water solubility | Complete | Complete |
Features:
-Broad spectrum kill and inhibit various types of microbial:
PHMB chemical is odourless and can be easily dissolved in water to form tasteless colorless transparent solution. It can be used as disinfectant for almost all kinds of bacteria.
-Excellent stability
Polyhexamethylene biguanide hydrochloride is still keep active after being heated at 280℃ for 15 min.
-Non-corrosive to metals
PHMB biocide is non-corrosive to copper, stainless steel, carbon steel and other metals.
Sterilization mechanism:
1. The guanidine group in Polyhexamethylene biguanide hydrochloride performs high activity and the polymer itself is cationic. Since bacteria and virus are usually anionic, they are easily to be absorbed by PHMB and could not divide and reproduce, and finally turn to inactive.
2. Polyhexamethylene biguanide hydrochloride (PHMB) collapses the cell membrane structure and form transmembrane stomata. Ultimately, it causes cell membrane rupture, disrupts for the energy metabolism of the organism, and disables the bacteria and virus.
3. The polymer forms a film that closes off the breathing passages of microorganisms, causing them to suffocate and die.
The sterilization mechanism is independent from the form and type of microorganisms. Even if the microorganisms mutate, the mutation will not affect their efficacy. Microorganisms do not produce resistance to PHMB.
Applications:
Polyhexamethylene biguanide hydrochloride (PHMB) can completely kill escherichia coli, staphylococcus aureus, candida Albicans, gonococcus, salmonella, pseudomonas aeruginosa, listeria, dysentery, aspergillus niger, brucella, vibrio parahaemolyticus, vibrio algolyticus, vibrio eels, Aeromonas hydrophilic, sulfate-reducing bacteria, iron bacteria, and saprophytic bacteria. It is suitable to care solutions for contact lenses, cosmetics, medical, pharmaceutical, skin, mucosa, vegetable, fruit, air, drinking water, swimming pool, paper making, tissue, sanitary pads, clothes, etc.
1.Disinfectant detergent for fruits and vegetables
After a lot of screening and comparison, the main active ingredients and auxiliary components of disinfectant detergents for fruits and vegetables have been fully studied. On this basis, PHMB disinfectant was selected.
Polyhexamethylene biguanide hydrochloride is the main component of the fruit and vegetable disinfectant detergent. It has the advantages of reliable sterilization effect, environmental protection, good stability and use. And can be used in high dilution, economic and cost-effective, conducive to the promotion of use.
In addition, PHMB and chlorhexidine acetate as the main components of polyhexamethylene biguanide hydrochloride compound disinfectant. It also has good bactericidal effect on the natural bacteria on the surface of fruits and vegetables. Its average logarithmic value of killing natural bacteria on the surface of cucumber, apple, grape and strawberry all reached above 2.08.
2. Antimicrobial finishing agent for fabrics
PHMB antimicrobial with dip-rolling, impregnation method or spray method to treat cotton and its blended fabrics after dyeing or printing. It can effectively inhibit the growth of bacteria. Its antibacterial properties remain effective after 10~100 washes at 50℃.
PHMB antimicrobial does not affect the main properties of textiles. It is suitable for use on most cotton fiber products.
PHMB disinfectant is a cationic oligomer. Its distribution is said to be 2 to 40 biguanide units. Each biguanide unit has 2 cationic groups. The high molecular weight Polyhexamethylene biguanide hydrochloride can form multiple adsorption points with the fiber surface, and the binding strength is high.
3. Used in contact lens care solution and female lotion
At present, PHMB and PAPB are the main active ingredients in contact lens care solution. They can recognize the phospholipid receptors on the surface of pathogenic microorganisms. Thus, they can selectively destroy the cell membrane of pathogenic microorganisms and kill the pathogens. BIGUANIDE antiseptic is less irritating and more effective, and can be used as the main component of female lotion.
Dosage:
PHMB biocide is usually formulated with other water treatment chemicals. The exact formula depends on water and equipment condition. The recommended dosage is 100~500 mg/L when used as a separate disinfectant. The dosage should be determined by exact process and method if applied in textile and printing, livestock-raising, and aquaculture.
Packing and Storage:
Store in a cool, dry, well-ventilated warehouse. Keep away from fire and heat source. Protect from direct sunlight. The package must be sealed and do not get wet. It should be stored separately from oxidizers, flammable and combustible materials.