Biocide Chemicals
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chemicals, professional service, experienced expert
and advanced technology.Biocides category as below:
aldehydes, halogens, hydantoins, isothiazolinones and
other environment-friendly biocides.
1,2-Benzisothiazolin-3(2H)-one
CAS No.:
2634-33-5
Molecular Formula:
C7H5NOS
Molecular Weight：
151.18
Structural Formula:
Properties：
1,2-Benzisothiazolin-3(2H)-one is an important bactericide and antiseptic. The BIT biocide can restrain microbes (fungi, germs, algae, etc.) from growing in an organic medium. It also can resolve any problem caused by microbe growing in an organic product. Such as mildewing, degeneration, and go bad.
1,2-Benzisothiazolin-3(2H)-one is stable over a broad pH range of 4–12 and a broad temperature range. BIT biocide is miscible in water and most low alcohols and glycols. BIT has low poison, and no irritation to the eyes and skin.
Specifications：
| Item | Index |
|---|---|
| Appearance | Slight yellow powder |
| Purity (HPLC) | ≥ 98% |
| Water | 31%~35% |
| Bolling point | 204°C~205°C |
| Melting point | 155°C~158°C |
| pH (1% solution) | 8.0~10 |
| Density (at 20°C) | 1.483 g/cm3 |
Synthesis：
1. Prepare the main raw material 2,2′ -dithiodibenzoic acid reaction formula.
2,2′ dithiobenzoic acid is not only the main raw material for 1,2-Benzisothiazolin-3(2H)-one production, but also an important pharmaceutical intermediate.
a. Polysulfide reaction:
b. Diazotization reaction:
c. Disulfide reaction:
d. Acidification reaction:
e. Aminolysis reaction:
f. Neutralization reaction:
2. Prepare 1,2-benzisothiazolinin-3-one (BIT) reaction formula.
a. Acyl chlorination reaction:
b. Bromination reaction:
c. Aminolysis reaction:
Applications：
1,2-Benzisothiazolin-3(2H)-one, miscible in water and of low toxicity. BIT biocide can be used to control the growth of microorganisms in emulsion paints, adhesives, concrete additives, and other water treatment formulations. Using quantum: 0.03-0.3% (w/w)
1,2-Benzisothiazolin-3(2H)-one has been widely used in papermaking, adhesives, chemical fibers, coatings (latex paint), pigments, polyurethane products, inks, latex tibia products, leather products, also used in cosmetics, washing products, drugs, food packaging materials, water treatment agents, oilfield water injection, industrial cooling water, and other industrial production fields. BIT synthesis is getting more and more attention.
This BIT biocide can be used as a preservative in manufacturing, metalworking fluids, pottery molding, plumbing, printing, and laboratory analysis; Used as a preservative in vinyl gloves.
Toxicity:
1,2-Benzisothiazolin-3(2H)-one (BIT) has been shown in animal studies with the mouse, rats, and rabbits to be of low acute toxicity.
In the solutions in which BIT is used, concentrations above 0.05 % are irritating to the skin. The allergenic effects begin at 0.05 % and have been confirmed in a series of case and patch test studies.
Nothing is known of systemic effects in men after uptake through the skin. Usable studies to determine whether BIT has carcinogenic activity have not been published to date.
Safety and Hazards:
This BIT biocide is harmful if swallowed. It can cause skin irritation and serious eye damage.1,2-Benzisothiazolin-3(2H)-one may cause an allergic skin reaction.
Avoid breathing dust. Contaminated work clothing should not be allowed out of the workplace.
Do not eat, drink or smoke when using this product. Wash skin thoroughly after handling.
Wear protective gloves, eye protection, and face protection. Wash with plenty of water if it is on the skin.
Packing:
Packed in 25kg fiber drum.
Synonyms:
1,2-Benzisothiazol-3(2H)-one; 2634-33-5; 1,2-Benzisothiazolin-3-one; 1,2-benzothiazol-3-one; benzisothiazolone; 1,2-Benzisothiazoline-3-one; benzoisothiazol-3-one; Benzisothiazolin-3-one; 1,2-Benzisothiazolone.
If you have any problems, just navigate to this post — Five Frequently Asked Questions About Benzisothiazolinone.