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1,2-Benzisothiazol-3(2H)-one, BIT Biocide

CAS No.:


Molecular Formula:


Molecular Weight:


Structural Formula:



1,2-Benzisothiazol-3(2H)-one (BIT) is an important bactericide and antiseptic. The BIT biocide can restrain microbe (fungi, germ, algae, etc.) growing in an organic medium. It also can resolve any problem caused by microbe growing in an organic product. Such as mildewing, degeneration, go bad.

1,2-Benzisothiazol-3(2H)-one (BIT) is stable over a broad pH range of 4–12 and a broad temperature range. BIT biocide is miscible in water and most of low alcohols and glycols. BIT has low poison, no irritation to eyes and skin.


AppearanceSlight yellow powder
Purity (HPLC)≥ 98%
Water≤ 15%
Melting point155-158°C
pH (1% solution)8.0-10


1. Prepare the main raw material 2,2′ -dithiodibenzoic acid reaction formula.

2,2′ dithiobenzoic acid is not only the main raw material for 1,2-Benzisothiazol-3(2H)-one production, but also an important pharmaceutical intermediate.

a. Polysulfide reaction:

polysulfide reaction

b. Diazotization reaction:

diazotization reaction

c. Disulfide reaction:

disulfide reaction

d. Acidification reaction:

acidification reaction

e. Aminolysis reaction:

aminolysis reaction

f. Neutralization reaction:

neutralization reaction

2. Prepare 1,2-benzisothiazolin-3-one (BIT) reaction formula.

a. Acyl chlorination reaction:

acyl chlorination reaction

b. Bromination reaction:

bromination reaction

c. Aminolysis reaction:

aminolysis reaction 2


1,2-Benzisothiazol-3(2H)-one, miscible in water and of low toxicity. BIT biocide can be used to control the growth of microorganisms in emulsion paints, adhesives, concrete additives, and other water treatment formulations. Using quantum: 0.03-0.3% (w/w)

BIT has been widely used in papermaking, adhesives, chemical fibers, coatings (latex paint), pigments, polyurethane products, inks, latex tibia products, leather products, also used in cosmetics, washing products, drugs, food packaging materials, water treatment agents, oilfield water injection, industrial cooling water and other industrial production fields. BIT synthesis is getting more and more attention.


Packed in 25kg fiber drum.


BIT; 1,2-Benzisothiazolin-3-One; Benzisothiazolinone; Proxan; Proxel; Proxil.

If you have any problems, just navigate to this post — Five Frequently Asked Questions About Benzisothiazolinone.