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2 2-Dibromo-3-Nitrilopropionamide (DBNPA)

CAS No.: 10222-01-2

Molecular Formula: C3H2Br2N2O

Molecular Weight: 242

Structural Formula:




DBNPA is white crystals. It is soluble in acetone, polyethyleneglycol, benzene, ethanol, etc. The DBNPA solubility is soluble in common organic solvents and slightly soluble in water.

DBNPA biocide is stable in acidic conditions and decomposed in alkaline conditions or in the presence of hydrogen sulfide.

The solid DBNPA is an efficient germicide for the recycling water system. It can penetrate in the cytocyst of microbes quickly and kill them by reacting with some proteins in it, stopping the redox of cells.

DBNPA solid biocide has a good stripping property, little poison, and no foam in the system. The organic solutions can miscible with water.

Synthetic Methods

1. Preparing chloroacetic acid, cyanoacetic acid, dialkyl aminoacrolein, amino-acetal, and methyl cyanoacetate as starting material. Cyanoacetamide is first made. And then you get the DBNPA biocide by Cyanoacetamide bromination.

2. The synthesis method of chloroacetic acid as starting materials: chloroacetic acid neutralizes sodium carbonate or sodium hydroxide to produce sodium chloroacetate.

Then sodium chloroacetate reacts with sodium cyanide in butanol solution to produce sodium of cyanoacetic acid. After acidizing it with concentrated hydrochloric acid.

The esterification reaction between cyanoacetic acid with methanol or butanol, get the methyl cyanoacetate. Then make Cyanoacetamide after aminolysis. At last, you get DBNPA by brominating.


Assay≥ 99%
Melting Point122-128℃
pH (1% Aqueous Solution)4.0-6.5
Loss on Drying≤ 1%


As the biocides in broad-spectrum, DBNPA biocide is widely used in industrial circulating water systems, large air-condition and the large center of sewage treatment to eliminate microorganisms and alga and shuck off clay. It is also used in the process of papermaking to prevent reducing the quality of paper by the generation of microorganisms.

This halogen biocide is suitable for metal cutting of cooling liquor, recovery system of oil, latex, and ply-woods as anti-spy biocides. It has the following advantages: easy to handle; no unusual oxidation hazards; similar performance and safety in paper and oilfield applications; used for slime control in the wet-end of the paper mill and performs exceptionally well against slime-forming bacteria.

DBNPA has exhibited outstanding efficiency against bio-films and against a broad spectrum of bacteria, fungus, and yeasts.

Additionally, DBNPA series products are used in the short-term preservation of coatings and coating additives such as latex, starch and mineral slurries.

DBNPA is a fast-acting/quick-kill biocide that is broad-spectrum and does not contain or release formaldehyde.

Package and Storage

25kg card drums with double PE inner bag or customers’ requirements. Store in a dry cool and ventilation environment.

The storage time is two years.


2 2-Dibromo-2-cyanoacetamide, 2 2-Dibromo-3-nitrilopropionamide, 10222-01-2, Dibromo cyanoacetamide.

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